Features
Ultrasensitive
Limit of detection down to 0.1% VAF
Comprehensive
Detects up to 500 COSMIC mutations
Quantitative
Accurate quantitation
Sample Flexibility
Compatible with several sample types
Sample Data
NuProbe’s BDA technology enriches the variant allele frequency (VAF) of mutations by over 200-fold, improving Sanger’s limit of detection of 20% VAF to 0.1% VAF.
Products
VarTrace™ EGFR Assay
Detects 400 mutations in exons 18, 19, 20, and 21 in FFPE and plasma samples
VarTrace™ AML Panel
Detects 254 AML hotspot mutations in FLT3, DNMT3A, IDH1, IDH2, KIT, NPM1 genes
VarTrace™ BRAF Assay
Detects mutations in codons 596–601 in FFPE and plasma samples
VarMap™: NGS
Features
Affordable
Only 1 million reads for liquid biopsy
Ultrasensitive
Limit of detection down to 0.1% VAF
Quantitative
>95% VAF quantitation accuracy
Sample Flexibility
Compatible with several sample types
Sample Data
VarMap NGS Panels preferentially amplify variant molecules, resulting in a reduction of required sequencing reads by 60-fold compared to deep sequencing approaches.
Products
VarMap™ NSCLC NGS Panel
Detects over 1100 COSMIC mutations in AKT1, ALK, BRAF, DDR2, EGFR, ERBB2, KRAS, MAP2K1, MET, NRAS, PIK3CA, PTEN, ROS1, and TP53
VarMAP™ Melanoma NGS Panel
Detects over 370 COSMIC mutations in AKT1, AKT3, BRAF, KRAS, MAP2K1, MAP2K2, NRAS, and PIK3CA
Coming Soon:
Varmap™ pan-cancer NGS Panel
Detect over 6500 COSMIC mutations in over 60 genes
VarMap™: Nanopore
Features
Rapid
Ultrafast turnaround enabling 10 hours DNA to results
Ultrasensitive
Limit of detection down to 0.1% VAF
Affordabble
Low sequencing cost
Sample Flexibility
Compatible with several sample types
Sample Data
Compared to standard nanopore sequencing, VarMap exhibits roughly 100-fold better mutation VAF limit of detection and roughly 10-fold higher throughput.
Products
VarMap™ AML Nanopore Panel
Detects 254 AML hotspot mutations in 6 genes: FLT3, DNMT3A, IDH1, IDH2, KIT, and NPM1
Customized Assays and Services
Features
Customizable
Automatically design custom BDA assays
Rapid Turnaround
qPCR, Sanger: 2-3 days
Rapid Prototype NGS Panel: 2 weeks
End-to-End NGS Panel Development: 6-12 weeks
Pan-Platform
qPCR, Sanger, and NGS
Ultrasensitive
Limit of detection down to 0.1% VAF
Sample Data
NGSure’s proprietary algorithm designs custom BDA assays with a limit of detection of 0.1% VAF, significantly expanding the range of mutations detected by NGS.
Products
NGSure qPCR/Sanger
Cost-effective customizable qPCR and Sanger-based BDA assays for the rapid and sensitive validation of variants identified by NGS.
Customized NGS design
Customizable NGS panel designs with 10-100 amplicons requiring less than 1 million reads. Two bespoke NGS design services available:
1) Rapid Prototype NGS Panel – custom panels designed and delivered in 2 weeks
2) End-to-End NGS Panel – custom panels designed and rigorously optimized by NuProbe’s expert team for delivery in 6-12 weeks
News & Press Releases
June 22, 2020
NuProbe and Weigao Group Form Strategic Collaboration to Develop Liquid Biopsy Panel
June 2, 2020
NuProbe Licensed Two Technologies from Rice University, Launched Nanopore AML multi-gene panel
April 22, 2020
March 16, 2020
February 26, 2020
NuProbe Announces Licensing Deal with Oxford Nanopore
January 6, 2020
Upcoming Events
June 22-24, 2020
AACR 2020 Virtual Annual Meeting II
October 27–31, 2020
Nov 17-21, 2020
AMP 2020 Annual Meeting & Expo
